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Radical Versus Partial Nephrectomy

Radical Versus Partial Nephrectomy
Cancer. 2009 Apr 1;115(7):1465-1471, L Zini, P Perrotte, U Capitanio, C Jeldres, SF Shariat, E Antebi, F Saad, JJ Patard, F Montorsi, PI Karakiewicz


Surgical removal of stage T1a renal cell carcinoma (RCC) typically involves partial nephrectomy (PN) or radical nephrectomy (RN).
The 2 procedures are associated with equivalent cancer-related outcomes. However, PN has the advantage of preserving parenchymal tissue and renal function. It may also be more likely than RN to protect patients from developing other morbid sequelae, including cardiovascular diseases, anemia, malnutrition, and neuropathy. In fact, a small previous study suggested an overall survival (OS) benefit for PN over RN in patients <65>

Zini et al conducted a large, population-based analysis using data from the Surveillance, Epidemiology, and End Results (SEER) registry to further explore mortality outcomes with PN and RN.
The results showed that patients with T1a RCC had lower mortality overall and from non−cancer-related causes when treated with PN rather than RN