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Calcium-Magnesium Combo Eases Oxaliplatin Sensory Effects

Calcium-Magnesium Combo Eases Oxaliplatin Sensory Effects

...The original plan had been to enroll 300 patients. But when only a third of that number had been randomized, unsubstantiated data from a separate trial testing FOLFOX (fluorouracil, leucovorin, and oxaliplatin) for colon cancer suggested that giving magnesium and calcium reduced the effectiveness of the treatment. Later, an independent review of that other trial eventually showed that in fact the magnesium/calcium group had a higher tumor response rate, but by then the current study had been closed.

The report by Dr. Loprinzi and colleagues includes data on 102 colon cancer patients on FOLFOX who received 1g calcium gluconate plus 1g magnesium sulfate pre- and post-oxaliplatin, or placebo. Data cutoff was done after four months and one week....