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ERCC1 Expression Predicts Treatment Outcome in Esophageal Adenocarcinoma - OncologySTAT

ERCC1 Expression Predicts Treatment Outcome in Esophageal Adenocarcinoma - OncologySTAT

...Pretreatment expression of ERCC1 in localized esophageal and gastroesophageal adenocarcinomas is a marker for outcomes among patients given trimodality therapy that includes oxaliplatin-based chemoradiation, investigators reported from a prospective study.

Fully 58% of the 55 patients studied from the Southwest Oncology Group (SWOG) S0356 trial had tumors expressing a high level of mRNA for ERCC1, a key gene in the repair of platinum- and radiation-induced DNA damage.