Longer Wait, Pre-Op Chemo Improves Rectal Cancer Outcomes

Longer Wait, Pre-Op Chemo Improves Rectal Cancer Outcomes:

"Neoadjuvant chemoradiation is standard for advanced rectal cancer, but a phase II trial shows that allowing more time for extra chemo before surgery leads to better tumor response rates."

ERCC1 Expression Predicts Treatment Outcome in Esophageal Adenocarcinoma - OncologySTAT

ERCC1 Expression Predicts Treatment Outcome in Esophageal Adenocarcinoma - OncologySTAT

...Pretreatment expression of ERCC1 in localized esophageal and gastroesophageal adenocarcinomas is a marker for outcomes among patients given trimodality therapy that includes oxaliplatin-based chemoradiation, investigators reported from a prospective study.

Fully 58% of the 55 patients studied from the Southwest Oncology Group (SWOG) S0356 trial had tumors expressing a high level of mRNA for ERCC1, a key gene in the repair of platinum- and radiation-induced DNA damage.

Chemoradiation Improves Disease Control in Bladder Cancer

Chemoradiation Improves Disease Control in Bladder Cancer

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Adding chemotherapy to radiation therapy caused 82% of people to be free of invasive bladder cancer 2 years after treatment," said study author Nicholas James, MD, professor of clinical oncology at the University of Birmingham, United Kingdom. "This compares with 68% who received radiation alone."

Preoperative chemoradiotherapy for rectal cancer: ... [Colorectal Dis. 2010] - PubMed result

Preoperative chemoradiotherapy for rectal cancer: ... [Colorectal Dis. 2010] - PubMed result

Preoperative chemoradiotherapy with capecitabine for rectal cancer is efficacious and comparable to 5-FU (IV). It is more convenient, is well tolerated and avoids the need for inpatient admission.